Casspi looked impressive as he scored 12 points in his first match since being traded by the Sacramento Kings.
The Israeli had not played since early January due to a calf injury but in a cruel twist of fate saw him injure his thumb when trying to steal the ball from a Rockets player in the third quarter.
"It's terrible luck and very frustrating but I've just got to try and recover as quickly as possible," said Casspi who is expected to be sidelined for four to six weeks.
With the Pelicans chasing a play-off place, the needed to release Casspi in order to sign a replacement. Under NBA rules the Pelicans will be required to pay the remainder of the $6 million two-year deal Casspi signed with the Kings.
Casspi could potentially join a team taking part in the final-16 play offs starting April but that is unlikely.
However, NBA commentators believe that the 6ft 9” forward should have no problems finding a team for next season.