Two American Jews, together with a non-Jewish German scientist, have won the Nobel Prize in medicine, pipping two Israelis to the post.
James Rothman and Randy Schekman, together with German researcher Thomas Suedhof, were awarded the accolade for their work on how proteins and other materials are transported within cells.
The Israelis, Hebrew University professors Aharon Razin and Howard Cedar, were very close contenders.
Mr Rothman is a professor at Yale University and Mr Schekman teaches at the University of California.