Canadian singer Alanis Morissette is being targeted by supporters of a cultural boycott of Israel over her plan to perform in the Jewish state.

The "Ironic" singer, a seven-time Grammy winner, is due to stage a concert in Tel Aviv on Monday, for the first time since a show in Israel in 2000. But the Palestinian Campaign for the Academic and Cultural Boycott of Israel is urging her to cancel at the last minute, because of the Israeli political situation.

"We would find it especially disturbing should you choose to play in Israel given its recent onslaught on Gaza," the campaign group said in an open message to the star. "Palestinian civil society groups are calling on artists to shun Tel Aviv in the same way that South African activists called on artists to boycott Sun City."

"We hope that you will not be persuaded by the argument that music builds bridges and can bring smiles to people's faces, thus hopefully spreading a message of peace," they added. "Any message of peace you hope to bring will be drowned by Israel's well-oiled publicity that will use you to rebrand itself as a normal state that promotes music and culture."

The singer, who is touring to promote her new album "Havoc and Bright Lights," is also being targeted by followers on Facebook and Twitter. One fan, responding to the comments about her Israel performance, wrote: "Please don't be bullied by the anti Israel sentiment. Go to Israel and see for yourself."