Liberal Democrat Lynne Featherstone failed to hang on to Hornsey and Wood Green, losing to her Labour rival Catherine West by 11,000 votes.
Her defeat leaves the Lib Dems with no women in Parliament.
Ms Featherstone, who was the most senior Jewish minister in the coalition, had held the north London seat since 2005, winning a majority of 6,000 five years ago.
Mrs West thanked her celebrity backers including actor Steve Coogan for helping her unseat Mrs Featherstone after a tensely fought campaign.