The charity attributes the decision to a decline in demand and says that from April, services will be provided through a communal hub from its Stepney premises, which will be renamed the Brenner Centre at Stepney Jewish Community Centre.
Staff directly impacted by the changes were told of the plans at a meeting on Tuesday.
Members and volunteers have been informed in person or by letter over the past few days.
The plan is to cut the full- and part-time staff responsible for day-care and outreach services at Brenner and Stepney from 26 to 11. Those without roles in the new structure will be offered “redeployment opportunities” within Jewish Care.