Budget airline Jet2 will stop running its Manchester to Israel route later this year.
The company began low-cost flights to Tel Aviv's Ben Gurion Airport almost four years ago.
It announced this week that the "difficult decision" had been taken to remove the route, but would not give a further explanation.
Jet2 has faced fierce competition from easyJet, which launched flights to Israel from Manchester a year ago. Ryanair has long been rumoured to be planning to start its own route to Tel Aviv.