This is Maccabi 22nd league title and first since 2016, ending a run of three titles by Hapoel Beer Sheva.
Maccabi's US Jewish striker Aaron Schoenfeld scored the winning goal in the 55th minute, when he bundled home a corner with his shoulder. The result gave Maccabi an unassailable 27- point lead at the top of the table, with eight games remaining.
Maccabi's manager Vladimir Ivic said: "We've done excellent work this season and to take the title in March is an incredible experience.
"No compliments are good enough for these players. Four years without the title is a long time for this club, but we can now sleep at night knowing we are the champions."